Alpha-GPC (Alpha Glyceryl Phosphoryl Choline, Choline alfoscerate) is a choline-containing phospholipid with cognitive enhancement capabilities, suggested to counteract cognitive decline in Alzheimer's disease, stroke, and other adult-onset dementia. Alpha-GPC is considered a parasympathetic agent used as a nutraceutical in many countries. Preclinical studies have shown that Alpha-GPC increases acetylcholine release and levels, as well as facilitating learning and memory. Alpha-GPC has been shown to increase acetylcholine levels in the aging brain. Acetylcholine is a neurotransmitter that contributes to communication between nerve cells and between neurons and their skeletal muscles and autonomic targets. It also plays a crucial role in the brain's ability to store and retrieve information. In clinical trials, Alpha-GPC has been found to improve cognition, behavior, and functional outcomes in patients with Alzheimer's disease, stroke, and cerebral ischemic attacks.

PUBLICATIONS ON THE SUBJECT:

** Nutrients. 2021 Jun 18;13(6):2091. doi: 10.3390/nu13062091.

Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study

** J Alzheimers Dis. 2023;92(1):59-70. doi: 10.3233/JAD-221189.

Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis

** J Clin Med. 2022 Oct 13;11(20):6052. doi: 10.3390/jcm11206052.

Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study

** Front Cell Neurosci. 2022 Sep 23;16:988759. doi: 10.3389/fncel.2022.988759.

Effects of choline containing phospholipids on the neurovascular unit: A review

** J Neurochem. 2019 May;149(4):499-517. doi: 10.1111/jnc.14560. Epub 2018 Nov 8.

Distinct disruptions in Land's cycle remodeling of glycerophosphocholines in murine cortex mark symptomatic onset and progression in two Alzheimer's disease mouse models