Schisandra Chinensis (SC) has been frequently used in China, Korea, and Japan for thousands of years as a tonic for the kidney and as a treatment to alleviate various symptoms of cognitive deficits and facilitate learning and memory. Recent clinical and laboratory experience has supported the idea that Schisandra Chinensis is safe and effective in improving cognitive function and reversing cycloheximide-induced amnesia in rats. Furthermore, lignans such as schizarin A, B, C, D, and E have been reported to exhibit antioxidant activity, and several other lignans, such as gomycin A, C, D, and G, along with gallotannins, have shown excellent inhibitory effects on AChE in various compounds. Schisandra Chinensis extract has the potential to reduce AChE activity and reverse oxidative damage both in vivo and in vitro. Through analyses in PC12 cells and a mouse model of Alzheimer's disease induced by scopolamine, Schisandra Chinensis extract exhibited potent neuroprotective effects due to antioxidant mechanisms. Furthermore, based on the determining activity of AChE, the effects of Schisandra Chinensis may be partly attributed to its potential to inhibit AChE activity. Therefore, Schisandra Chinensis extract may serve as a supporting actor in a multifunctional treatment for Alzheimer's disease. The application of Schisandra Chinensis extract was a potentially effective and simple strategy to improve learning and memory abilities in the elderly and could be a viable support in preventing the development of Alzheimer's disease.

PUBLICATIONS ON THE SUBJECT:

** Biomed Pharmacother.2018 Jan;97:958-968.doi: 10.1016/j.biopha.2017.10.145.

An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis

** Molecules. 2018 Apr 10;23(4):870.doi: 10.3390/molecules23040870.

Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ1-42-Induced Memory Impairment in Rats and Neurotoxicity in Primary Neuronal Cells

** Oxid Med Cell Longev. 2022 Jul 11;2022:6362617. doi: 10.1155/2022/6362617. eCollection 2022.

Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis

** Evid Based Complement Alternat Med. 2020 Feb 20;2020:2804849.doi: 10.1155/2020/ 2804849.

In Vitro and In Vivo Anti-AChE and Antioxidative Effects of Schisandra chinensis Extract: A Potential Candidate for Alzheimer's Disease

** Indian J Pharmacol.2020 Mar-Apr;52(2):94-101.doi:10.4103/ijp.IJP_515_19.Epub 2020 Jun 3

Network pharmacology-based study on the mechanism of Schisandra chinensis for treating Alzheimer's disease

** J Ethnopharmacol.2019 Jun 12;237:354-365.doi:10.1016/j.jep.2019.02.046.Epub 2019 Mar 4.

Polysaccharide of Schisandra Chinensis Fructus ameliorates cognitive decline in a mouse model of Alzheimer's disease

** Int J Mol Sci. 2018 Jul 6;19(7):1970.doi: 10.3390/ijms19071970.

Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases

** Molecules. 2019 Mar 27;24(7):1203. doi: 10.3390/molecules24071203.

Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC⁻Q-TOF-MS

** PLoS One. 2016 Apr 1;11(4):e0152772.doi: 10.1371/journal.pone.0152772. eCollection 2016.

Total Lignans of Schisandra chinensis Ameliorates Aβ1-42-Induced Neurodegeneration with Cognitive Impairment in Mice and Primary Mouse Neuronal Cells